%PDF-1.7
%
69 0 obj
<>>>/Metadata 133 0 R/OpenAction 70 0 R/Outlines 60 0 R/PageLayout/TwoPageRight/Pages 65 0 R/Type/Catalog/ViewerPreferences<>>>
endobj
133 0 obj
<>stream
application/pdf
©2014 Thermo Fisher Scientific Inc. All rights reserved. Kollidon is a registered trademark of BASF Aktiengesellschaft Corporation. All other trademarks are the property of Thermo Fisher Scientific and its subsidiaries. This information is presented as an example of the capabilities of Thermo Fisher Scientific products. It is not intended to encourage use of these products in any manners that might infringe the intellectual property rights of others. Specifications, terms and pricing are subject to change. Not all products are available in all countries. Please consult your local sales representative for details.
FT-NIR spectroscopy has been successfully applied to the characterization of clear extrudates using transmission probes located in the extruder die. This study has demonstrated the feasibility of monitoring levels of two components simultaneously and in real-time, the API and plasticizer. Here, due to the limited number of calibration samples available, a simple one wavenumber calibration was applied to the data set. A greater number of samples would enable more robust calibrations to be performed by reducing the interference from overlapping absorptions using PLS regression.
Drug Solubility
Near-infrared
Pharmaceutical Extrusion
Process Analytics
Application Note 52565. FT-NIR spectroscopy has been successfully applied to the characterization of clear extrudates using transmission probes located in the extruder die. This study has demonstrated the feasibility of monitoring levels of two components simultaneously and in real-time, the API and plasticizer. Here, due to the limited number of calibration samples available, a simple one wavenumber calibration was applied to the data set. A greater number of samples would enable more robust calibrations to be performed by reducing the interference from overlapping absorptions using PLS regression.
2014-03-21T13:55:33.478-04:00
Adrian Kelly,Centre of Pharmaceutical Engineering Science,University of Bradford,Yorkshire,United Kingdom,Sheelagh Halsey,Thermo Fisher Scientific,Hemel Hempstead,Mark Terrell,Madison,Wisconsin,USA
The Use of Transmission FT-NIR Analysis for the simultaneous analysis of Carbamazepine and PEG 2000 in Extrudates
2014-02-18T14:32:44-05:00
2014-02-18T12:26:15-05:00
2014-02-18T14:32:44-05:00
Adobe InDesign CC (Macintosh)
proof:pdf
converted
from application/x-indesign to application/pdf
Adobe InDesign CC (Macintosh)
/
2014-02-18T11:26:15-06:00
xmp.id:116c1a53-3492-40e4-860e-482b4a2799dd
xmp.did:A9CC217428206811822AE847A0C17DD4
uuid:a580c53f-6586-43b4-8828-86be08c45328
default
xmp.iid:8e5e5d06-13ff-41ec-8c27-3bcf32c6bf85
xmp.did:5fb3aaaa-438c-4253-a4dd-47f479ff95ea
xmp.did:A9CC217428206811822AE847A0C17DD4
9d82575d5740c94f329b889f4da6f977062f7d09
2014-03-21T13:55:30.688-04:00
Adobe PDF Library 10.0.1
False
Adrian Kelly
Drug Solubility; Near-infrared; Pharmaceutical Extrusion; Process Analytics
Adobe PDF Library 10.0.1
False
document-taxonomy:scientific-resources/application-notes
True
endstream
endobj
70 0 obj
<>
endobj
60 0 obj
<>
endobj
65 0 obj
<>
endobj
71 0 obj
<>/ExtGState<>/Font<>/Pattern<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Tabs/W/Thumb 61 0 R/TrimBox[0.0 0.0 594.0 792.0]/Type/Page>>
endobj
1 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Tabs/W/Thumb 62 0 R/TrimBox[0.0 0.0 594.0 792.0]/Type/Page>>
endobj
15 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/Rotate 0/Tabs/W/Thumb 63 0 R/TrimBox[0.0 0.0 594.0 792.0]/Type/Page>>
endobj
27 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Tabs/W/Thumb 64 0 R/TrimBox[0.0 0.0 594.0 792.0]/Type/Page>>
endobj
28 0 obj
<>stream
HW[o~篘 ޙٹO)hDI
RrD;3R ;37?b`¿S!wa24X W/Vg+)O ήWFbDX7VY&78ۭOCvKZ?k] 5?Dj!oD%d !Q\wۯՠxAv=kWB oz{#nЃNN8vnOanGdU{qK\aLnr&:C:}#{^kLj^le{:T;&Ck-ξvIfWsgd-|Lb-Ip-xTYNRa"N&E oȬw?cK13A91%qw}4S2H߽ ߳K|Imҝ_~PO@\%6OnB`'-ע_& <5Q^el$}/n9V<9@§Fe5b
Bf@w,e$i=+V9 ;OϋvƠ% N